Synthetic Antimicrobial Peptides Fail to Induce Leucocyte Innate Immune Functions but Elicit Opposing Transcriptomic Profiles in European Sea Bass and Gilthead Seabream

Synthetic Antimicrobial Peptides Fail to Induce Leucocyte Innate Immune Functions but Elicit Opposing Transcriptomic Profiles in European Sea Bass and Gilthead Seabream

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Antimicrobial peptides (AMPs) are promising molecules in diverse fields, including aquaculture.AMPs possess lytic effects on a wide range of pathogens, resulting in a potential replacement for traditional antimicrobials in aquaculture.In addition, they also have modulatory effects on host immune responses.Thus, the Facial Cleansers objective of this work was to evaluate the immunomodulatory capability of three known synthetic AMPs derived from European sea bass, NK-lysin (Nkl), hepcidin (Hamp), and dicentracin (Dic), in head-kidney cell suspensions from European sea bass and gilthead seabream.

The tested peptides were neither cytotoxic for European sea bass nor gilthead seabream cells and failed to modulate the respiratory burst and phagocytosis activities.However, they modified the pattern of transcription of immune-related genes differently in both species.Peptides were able to promote the expression of marker genes for anti-inflammatory (il10), antiviral (mx, irf3), cell-mediated cytotoxicity (nccrp1, gzmb), and antibody responses (ighm) in European sea bass, with the Nkl peptide being the most effective.Contrary to this, the effects of those peptides on gilthead seabream mainly resulted in the suppression of immune responses.

To conclude, European sea bass-derived peptides can be postulated as potential tools for immunostimulation Beko XDVG675SM Dark Silver Mirrored Gas Cooker Double Oven 60cm in European sea bass fish farms, but more efforts are required for their universal use in other species.